Dynamically driven protein allostery
نویسندگان
چکیده
منابع مشابه
Dynamically Driven Protein Allostery Exhibits Disparate Responses for Fast and Slow Motions.
There is considerable interest in the dynamic aspect of allosteric action, and in a growing list of proteins allostery has been characterized as being mediated predominantly by a change in dynamics, not a transition in conformation. For considering conformational dynamics, a protein molecule can be simplified into a number of relatively rigid microdomains connected by joints, corresponding to, ...
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It is becoming increasingly clear that the fundamental capacity to undergo conformational change in response to ligand binding is intrinsic to proteins. This property confers on proteins the ability to be allosterically modulated in order to shift substrate binding affinities, alter enzymatic activity or regulate protein-protein interaction. How this allosteric modulation occurs--the pathways o...
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ژورنال
عنوان ژورنال: Nature Structural & Molecular Biology
سال: 2006
ISSN: 1545-9993,1545-9985
DOI: 10.1038/nsmb1132